Involved in a car accident, Marie Cotnoir suffered an injury to her left frontal lobe at 22 years old. Caty Enders highlights how Cotnoir has worked through rehabilitation to recover from her injury, and how after six years considers herself recovered, despite effects from her brain injury that leave her isolated.

Having experienced and recovered from a brain injury, Kelsey Padgett decided to investigate the lives of those who do not have the chance to return to their old lives. Padgett speaks to Joel Fusier about the car accident that gave him his brain injury, the journey Joel went on to recover, and how he copes with his injury today.

A former violinist, Carole Starr suffered a brain injury that causes her to feel discomfort and confusion around music and other sounds. Staff discusses her former life as a violinist, the sacrifices she has had to make due to her brain injury, and how she tries to finds ways to still incorporate music into her life.

Attacked in their home during the middle of the night, Melanie Guerrette speaks about how her families life changed after that night. Bradley Cambell speaks to the family about struggling with traumatic brain injuries, and discusses how Melanie works to keep her family together.

Living with brain injuries since shortly after birth, Rebecca Lee attends Carlisle Academy to have horse therapy. Mary Wesley documents the therapy Lee receives at Carlisle, and how her life has changed thanks to her riding.

Following the death of her husband, Anne Murray Mozingo was asked by Stanley Medical Research Institute if they could use a part of her husbands brain for research. Katrina Roi investigates how the institute took more than they asked for, and the legal debate Mozingo became involved with regarding tissue donation.

Wolfgang Daniel documents how a woman who is living with brain damage and memory loss pieces together life through scattered images.

When Josh Howe returned home from the hospital after having a brain tumor removed, his sister Morgan started to get frustrated. Kim Alexander documents how the family has coped with Josh's condition.

Kelli Gavant highlights the life of Phyllis Rogers, a teacher with SPIRAL Arts, Inc., who suffers from chronic pain following an accident that damaged her brain. Gavant discusses the work that SPIRAL Arts does for their students and how it has helped Rogers and others.

Pete Chase, who suffers from a degenerative brain disease has begun to contemplate suicide, with the support of his wife. Morgan Springer documents how Sophie and Pete have tried to cope with Pete's brain disease, and their decision that suicide might be the answer.

When Josh Howe returned home from the hospital after having a brain tumor removed, his sister Morgan started to get frustrated. Kim Alexander documents how the family has coped with Josh's condition.

After suffering nine concussions, artist Raphael Diluzio woke up one morning not knowing his own identity. Shara Morris speaks to Diluzio about having to relearn to draw, and how his art helped with his recovery process.